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Inflammopharmacology:益生菌治疗类风湿关节炎,似乎无效

Inflammopharmacology

2018-01-04Article

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影响因子

原标题:益生菌补充剂在类风湿关节炎治疗中的疗效:一项对随机对照试验的荟萃分析

① 共计153名受试者的4项随机对照试验纳入荟萃分析;② 与安慰剂相比,补充益生菌并没有显著性地改变炎症参数(红细胞沉降率、TNF-α、IL1β、IL-6、IL-10、IL-12)和氧化应激指标(总抗氧化能力和丙二醛含量);③ C反应蛋白显著降低,疾病活动度评分(DAS)显著提高;④ 由于试验数量太少,无法确定是否存在应变、剂量或持续反应效应;⑤ 益生菌在类风湿关节炎治疗中似乎没有多大疗效,需要进一步的证据得出确切的结论。

荟萃分析益生菌类风湿关节炎Disease activityInflammatory factorsMETA-ANALYSISprobioticsRandomized trialrheumatoid arthritis

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2018-01-11 16:11this little piggy推荐

Title:
The efficacy of probiotic supplementation in rheumatoid arthritis: a meta-analysis of randomized, controlled trials

DOI:
10.1007/s10787-017-0436-y

Abstract & Authors:展开

Abstract:
Probiotics are considered as -immunomodulatory agents; their efficacy as an adjunct therapy option for rheumatoid arthritis (RA), however, remains controversial. The main aim of the present meta-analysis, therefore, was to compare available data from the published randomized, controlled trials (RCTs) recruiting adults with RA which compared probiotics with placebo. The English literature search was performed using Ovid version of Medline, EmBase, Web of Science, and the Central Cochrane library through October 2016 and supplemented by hand searching reference lists. Among 240 citations identified, 4 RCTs (153 participants; 89% female) were included. All data were pooled using a standardized mean difference (SMD) with a 95% CI. Compared to the placebo, probiotics did not change the inflammatory parameters (erythrocyte sedimentation rate, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-10, and IL-12) and oxidative stress indices (total antioxidant capacity and malondialdehyde) significantly. The borderline significant reduction as a result of probiotic administration was only determined in C-reactive protein [SDM - 0.32 (95% CI - 0.65 to 0.00)]. Among disease activity indices (disease activity score [DAS], tender joint count, and swollen joint count), DAS showed a significant improvement following probiotic treatment with a SMD (95% CI) of - 0.58 (- 0.97 to - 0.19). The number of trials was too small to determine if a strain-, dose-, or duration-response effect was present. Probiotics seem to be less effective in RA; however, to reach a firm conclusion, we need further evidence.

All Authors:
Seyed Mohammad Aqaeinezhad Rudbane,Samane Rahmdel,Seyedeh Maryam Abdollahzadeh,Morteza Zare,Azam Bazrafshan,Seyed Mohammad Mazloomi

First Authors:
Seyed Mohammad Aqaeinezhad Rudbane

Correspondence:
Seyedeh Maryam Abdollahzadeh

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